Lab Publications
1. Ganguly, Saptarnab, Tandrika Chattopadhyay, Rubina Kazi, Souparno Das, Bhavisha Malik, Uthpala Ml, Padmapriya S. Iyer et al. "Consumption of sucrose-water rewires macronutrient uptake and utilization mechanisms in a tissue specific manner." The Journal of Nutritional Biochemistry 139 (2025): 109850.
2. Khatri, Subhash, Souparno Das, Anshit Singh, Shabbir Ahmad, Mohit Kashiv, Sunil Laxman, and Ullas Kolthur‐Seetharam. "Diurnal variation in skeletal muscle mitochondrial function dictates time‐of‐day‐dependent exercise capacity." The FASEB Journal 39, no. 3 (2025): e70365.
3. Satheesan, Sandra Usha, Shreyam Chowdhury, and Ullas Kolthur-Seetharam. "Metabolic and circadian inputs encode anticipatory biogenesis of hepatic fed microRNAs." Life Science Alliance 7.5 (2024).
4. Talwadekar, Manasi, Subhash Khatri, Chinthapalli Balaji, Arnab Chakraborty, Nandini-Pal Basak, Siddhesh S. Kamat, and Ullas Kolthur-Seetharam. "Metabolic transitions regulate global protein fatty acylation." Journal of Biological Chemistry300, no. 1 (2024).
5. Sen, Devashish, Babukrishna Maniyadath, Shreyam Chowdhury, Arshdeep Kaur, Subhash Khatri, Arnab Chakraborty, Neelay Mehendale et al. "Metabolic regulation of CTCF expression and chromatin association dictates starvation response in mice and flies." Iscience 26, no. 7 (2023).
6. Khatri, Subhash, Rubina Kazi, and Ullas Kolthur-Seetharam. "Shaping mitochondria through fed–fast and circadian cycles." Biochemical Journal 480.13 (2023): 909-919.
7. Shukla, Namrata, and Ullas Kolthur‐Seetharam. "Drosophila Sirtuin 6 mediates developmental diet‐dependent programming of adult physiology and survival." Aging Cell21.3 (2022): e13576.
8. Shukla, Namrata, Shantanu Kadam, Ranjith Padinhateeri, and Ullas Kolthur-Seetharam. "Continuous variable responses and signal gating form kinetic bases for pulsatile insulin signaling and emergence of resistance." Proceedings of the National Academy of Sciences 118, no. 41 (2021): e2102560118.8.
9. Maniyadath, Babukrishna, U. S. Sandra, and Ullas Kolthur-Seetharam. "Metabolic choreography of gene expression: nutrient transactions with the epigenome." Journal of biosciences 45.1 (2020): 7.
10. Sandra, U. S., Arushi Shukla, and Ullas Kolthur-Seetharam. "Search and capture: disorder rules gene promoter selection." Trends in Genetics 36, no. 10 (2020): 721-722.
11. Chattopadhyay, Tandrika, Babukrishna Maniyadath, Hema P. Bagul, Arindam Chakraborty, Namrata Shukla, Srikanth Budnar, Abinaya Rajendran, Arushi Shukla, Siddhesh S. Kamat, and Ullas Kolthur-Seetharam. "Spatiotemporal gating of SIRT1 functions by O-GlcNAcylation is essential for liver metabolic switching and prevents hyperglycemia." Proceedings of the National Academy of Sciences 117, no. 12 (2020): 6890-6900.
12. Shaw, Eisha, Manasi Talwadekar, Zeenat Rashida, Nitya Mohan, Aishwarya Acharya, Subhash Khatri, Sunil Laxman, and Ullas Kolthur-Seetharam. "Anabolic SIRT4 exerts retrograde control over TORC1 signaling by glutamine sparing in the mitochondria." Molecular and cellular biology 40, no. 2 (2020): e00212-19.
13. Deota, Shaunak, Sivasudhan Rathnachalam, Kanojia Namrata, Mayank Boob, Amit Fulzele, S. Radhika, Shubhra Ganguli et al. "Allosteric regulation of cyclin-B binding by the charge state of catalytic lysine in CDK1 is essential for cell-cycle progression." Journal of molecular biology 431, no. 11 (2019): 2127-2142.
14. Maniyadath, Babukrishna, Tandrika Chattopadhyay, Srikant Verma, Sujata Kumari, Prineeta Kulkarni, Kushal Banerjee, Asmitha Lazarus et al. "Loss of hepatic oscillatory fed microRNAs abrogates refed transition and causes liver dysfunctions." Cell reports 26, no. 8 (2019): 2212-2226.
15. Parik, Sweta, Sandipan Tewary, Champakali Ayyub, and Ullas Kolthur-Seetharam. "Loss of mitochondrial SIRT4 shortens lifespan and leads to a decline in physical activity." Journal of Biosciences 43 (2018): 243-247.
16. Maniyadath, Babukrishna, Namrata Shukla, and Ullas Kolthur-Seetharam. "Gene expression, epigenetics and ageing." Biochemistry and Cell Biology of Ageing: Part I Biomedical Science (2018): 471-504.
17. Banerjee, Kushal K., Rujuta S. Deshpande, Pranavi Koppula, Champakali Ayyub, and Ullas Kolthur-Seetharam. "Central metabolic sensing remotely controls nutrient-sensitive endocrine response in Drosophila via Sir2/Sirt1–upd2–IIS axis." Journal of Experimental Biology 220, no. 7 (2017): 1187-1191.
18. Deota, Shaunak, Tandrika Chattopadhyay, Deepti Ramachandran, Eric Armstrong, Beatriz Camacho, Babukrishna Maniyadath, Amit Fulzele, Anne Gonzalez-de-Peredo, John M. Denu, and Ullas Kolthur-Seetharam. "Identification of a tissue-restricted isoform of SIRT1 defines a regulatory domain that encodes specificity." Cell reports 18, no. 13 (2017): 3069-3077.
19. Deota, Shaunak, Namrata Shukla, and Ullas Kolthur-Seetharam. "Spatio-Temporal Control of Cellular and Organismal Physiology by Sirtuins." Journal of the Indian Institute of Science 97 (2017): 147-159.
20. Ghosh, S., K. K. Banerjee, V. A. Vaidya, and U. Kolthur‐Seetharam. "Early stress history alters serum insulin‐like growth factor‐1 and impairs muscle mitochondrial function in adult male rats." Journal of Neuroendocrinology 28, no. 9 (2016).
21. Banerjee, Kushal K., Champakali Ayyub, Samudra Sengupta, and Ullas Kolthur-Seetharam. "Fat body dSir2 regulates muscle mitochondrial physiology and energy homeostasis nonautonomously and mimics the autonomous functions of dSir2 in muscles." Molecular and cellular biology 33, no. 2 (2013): 252-264.
22. Ho, Linh, Allen Sam Titus, Kushal Kr Banerjee, Suji George, Wei Lin, Shaunak Deota, Asish K. Saha et al. "SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK." Aging (Albany NY) 5, no. 11 (2013): 835.
23. Lazarus, Asmitha, Kushal Kr Banerjee, and Ullas Kolthur-Seetharam. "Small changes, big effects: chromatin goes aging." Epigenetics: Development and Disease (2013): 151-176.
24. Banerjee, Kushal Kr, Champakali Ayyub, Syed Zeeshan Ali, Vinesh Mandot, Nagaraj G. Prasad, and Ullas Kolthur-Seetharam. "dSir2 in the adult fat body, but not in muscles, regulates life span in a diet-dependent manner." Cell reports 2, no. 6 (2012): 1485-1491.
25. Banerjee, Kushal Kr, Champakali Ayyub, Samudra Sengupta, and Ullas Kolthur-Seetharam. "dSir2 deficiency in the fatbody, but not muscles, affects systemic insulin signaling, fat mobilization and starvation survival in flies." Aging (Albany NY) 4, no. 3 (2012): 206.
26. Ramachandran, Deepti, Upasana Roy, Swati Garg, Sanchari Ghosh, Sulabha Pathak, and Ullas Kolthur‐Seetharam. "Sirt1 and mir‐9 expression is regulated during glucose‐stimulated insulin secretion in pancreatic β‐islets." The FEBS journal 278, no. 7 (2011): 1167-1174.
27. Ghosh, Sanchari, Suji George, Upasana Roy, Deepti Ramachandran, and Ullas Kolthur-Seetharam. "NAD: a master regulator of transcription." Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1799, no. 10-12 (2010): 681-693.
28. Kolthur-Seetharam, Ullas, Madapura M. Pradeepa, Nikhil Gupta, Rammohan Narayanaswamy, and Manchanahalli R. Satyanarayana Rao. "Spatiotemporal organization of AT-and GC-rich DNA and their association with transition proteins TP1 and TP2 in rat condensing spermatids." Journal of Histochemistry & Cytochemistry 57, no. 10 (2009): 951-962.
29. Kolthur-Seetharam, Ullas, Katja Teerds, Dirk G. de Rooij, Olivia Wendling, Michael McBurney, Paolo Sassone-Corsi, and Irwin Davidson. "The histone deacetylase SIRT1 controls male fertility in mice through regulation of hypothalamic-pituitary gonadotropin signaling." Biology of reproduction 80, no. 2 (2009): 384-391.
30. Kolthur-Seetharam, Ullas, Igor Martianov, and Irwin Davidson. "Specialization of the general transcriptional machinery in male germ cells." Cell Cycle 7, no. 22 (2008): 3493-3498.
31. Kolthur-Seetharam, Ullas, Françoise Dantzer, Michael W. McBurney, Gilbert de Murcia1, and Paolo Sassone-Corsi. "Control of AIF-mediated cell death by the functional interplay of SIRT1 and PARP-1 in response to DNA damage." Cell cycle5, no. 8 (2006): 873-877.
32. Ullas, Kolthur S., and Manchanahalli RS Rao. "Phosphorylation of rat spermatidal protein TP2 by sperm-specific protein kinase A and modulation of its transport into the haploid nucleus." Journal of Biological Chemistry 278, no. 52 (2003): 52673-52680.
Collaborative work
1. Ghai, Utkarsha, Parul Chachra, Suchith Mendon, Balaganesh Janakiraman, Sashaina E. Fanibunda, Ambalika Sarkar, Dievya Gohil et al. "Postnatal and juvenile fluoxetine treatment evokes sex-specific, opposing effects on mood-related behavior, gene expression, mitochondrial function, and dendritic architecture in the rat medial prefrontal cortex." Biological Psychiatry (2025).
2. Fanibunda, Sashaina E., Kowshik Kukkemane, Utkarsha Ghai, Ullas Kolthur-Seetharam, Lal Hingorani, Ashok DB Vaidya, and Vidita A. Vaidya. "Withania somnifera Regulates Mitochondrial Biogenesis and Energetics in Rat Cortical Neurons: Role of BDNF and SIRT1." Molecular Neurobiology(2025): 1-19.
3. Deota, Shaunak, Julie S. Pendergast, Ullas Kolthur-Seetharam, Karyn A. Esser, Frédéric Gachon, Gad Asher, Charna Dibner et al. "The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research." Nature metabolism (2025): 1-15.
4. Chakraborty, Arnab, Prajwal Punnamraju, Theja Sajeevan, Arshdeep Kaur, Ullas Kolthur-Seetharam, and Siddhesh S. Kamat. "Identification of ABHD6 as a lysophosphatidylserine lipase in the mammalian liver and kidneys." Journal of Biological Chemistry 301, no. 2 (2025): 108157.
5. Vishwakarma, Krishna Kant, Ullas Seetharam Kolthur, and Ravindra Venkatramani. "Multiple Functional Protein–Protein Interaction Interfaces Allosterically Regulate ATP‐Binding in Cyclin‐Dependent Kinase‐1." Proteins: Structure, Function, and Bioinformatics 92, no. 11 (2024): 1329-1342.
6. Chhatar, Sushanta, Shubhankar Gadre, Subhadeep Paul, Shreyas P. Vaidya, Subhash Khatri, Prakash Duari, Jyoti Kode, Arvind Ingle, Ullas Kolthur‐Seetharam, and Malay Patra. "Improving In Vivo Tumor Accumulation and Efficacy of Platinum Antitumor Agents by Electronic Tuning of the Kinetic Lability." Chemistry-A European Journal 30, no. 4 (2024).
7. Prakhar, Praveen, Bharat Bhatt, Gaurav Kumar Lohia, Awantika Shah, Tanushree Mukherjee, Ullas Kolthur-Seetharam, Nagalingam R. Sundaresan, Raju S. Rajmani, and Kithiganahalli Narayanaswamy Balaji. "G9a and Sirtuin6 epigenetically modulate host cholesterol accumulation to facilitate mycobacterial survival." PLoS Pathogens 19, no. 10 (2023): e1011731.
8. Singla, A., P. Chaudhari, M. Hingmire, D. Kapri, S. E. Fanibunda, S. Suryavanshi, U. Kolthur-Seetharam, P. Govindaraj, and V. A. Vaidya. "Substrain-dependent effects of physical exercise on brain mitochondrial and neurotrophic measures in C57Bl/6N-derived mouse substrains." Neuroscience Applied 2 (2023): 103070.
9. Chaudhari, P., A. Singla, K. Kukkemane, S. Suryavanshi, S. Fanibunda, P. Tiwari, V. Dewan et al. "Early life adversity perturbs mitostasis and drives inflammaging in the rat hippocampus." Neuroscience Applied 2 (2023): 103044.
10. Gadre, Shubhankar, M. Manikandan, Prakash Duari, Sushant Chhatar, Astha Sharma, Subhash Khatri, Jyoti Kode et al. "A Rationally Designed Bimetallic Platinum (II)‐Ferrocene Antitumor Agent Induces Non‐Apoptotic Cell Death and Exerts in Vivo Efficacy." Chemistry–A European Journal 28, no. 46 (2022): e202201259.
11. Khan, Danish, Mohsen Sarikhani, Subhajit Dasgupta, Babukrishna Maniyadath, Anwit S. Pandit, Sneha Mishra, Faiz Ahamed et al. "SIRT6 deacetylase transcriptionally regulates glucose metabolism in heart." Journal of Cellular Physiology233, no. 7 (2018): 5478-5489.
12. Dhami-Shah, Hiteshi, Rama Vaidya, Manasi Talwadekar, Eisha Shaw, Shobha Udipi, Ullas Kolthur-Seetharam, and Ashok DB Vaidya. "Intervention by picroside II on FFAs induced lipid accumulation and lipotoxicity in HepG2 cells." Journal of Ayurveda and Integrative Medicine 12, no. 3 (2021): 465-473.
13. Khan, Danish, Tarannum Ara, Venkatraman Ravi, Raksha Rajagopal, Himani Tandon, Jayadevan Parvathy, Edward A. Gonzalez et al. "SIRT6 transcriptionally regulates fatty acid transport by suppressing PPARγ." Cell reports 35, no. 9 (2021).
14. Das, Anirban, Vicky Vishvakarma, Ankur Gupta, Simli Dey, Arpan Dey, U. Sandra, Ullas Kolthur et al. "Factors that Affect the Binding of the N-Terminal Helix of Human ACE2 to Spike Protein of SARS-CoV2." Biophysical Journal 120, no. 3 (2021): 15a.
15. Malani, Anup, Daksha Shah, Gagandeep Kang, Gayatri Nair Lobo, Jayanthi Shastri, Manoj Mohanan, Rajesh Jain et al. "Seroprevalence of SARS-CoV-2 in slums versus non-slums in Mumbai, India." The Lancet Global Health 9, no. 2 (2021): e110-e111.
16. Maity, Ayan, U. S. Sandra, Ullas Kolthur-Seetharam, and Vivek Polshettiwar. "Dendritic fibrous nanosilica (DFNS) for RNA extraction from cells." Langmuir 36, no. 42 (2020): 12755-12759.
17. Ravi, Venkatraman, Aditi Jain, Danish Khan, Faiz Ahamed, Sneha Mishra, Malyasree Giri, Meena Inbaraj et al. "SIRT6 transcriptionally regulates global protein synthesis through transcription factor Sp1 independent of its deacetylase activity." Nucleic Acids Research 47, no. 17 (2019): 9115-9131.
18. Fanibunda, Sashaina E., Sukrita Deb, Babukrishna Maniyadath, Praachi Tiwari, Utkarsha Ghai, Samir Gupta, Dwight Figueiredo et al. "Serotonin regulates mitochondrial biogenesis and function in rodent cortical neurons via the 5-HT2A receptor and SIRT1–PGC-1α axis." Proceedings of the National Academy of Sciences 116, no. 22 (2019): 11028-11037.
19. Dhami-shah, Hiteshi, Rama Vaidya, Manasi Talwadekar, Eisha Shaw, Shobha Udipi, Ullas Kolthur-seetharam, and Ashok Vaidya. "13. Picroside ii reduces lipid accumulation, oxidative stress and mitochondrial dysfunction in in vitro NAFLD HePG2 cell model." Journal of Clinical and Experimental Hepatology 8 (2018): S40-S41.
20. Muralidharan, Bhavana, Zeba Khatri, Upasana Maheshwari, Ritika Gupta, Basabdatta Roy, Saurabh J. Pradhan, Krishanpal Karmodiya et al. "LHX2 interacts with the NuRD complex and regulates cortical neuron subtype determinants Fezf2 and Sox11." Journal of Neuroscience 37, no. 1 (2017): 194-203.
21. Sehgal, Lalit, Amitabha Mukhopadhyay, Anandi Rajan, Nileema Khapare, Mugdha Sawant, Sonali S. Vishal, Khyati Bhatt et al. "14-3-3γ-Mediated transport of plakoglobin to the cell border is required for the initiation of desmosome assembly in vitro and in vivo." Journal of cell science 127, no. 10 (2014): 2174-2188.
22. Mehta, Ishita S., Mugdha Kulashreshtha, Sandeep Chakraborty, Ullas Kolthur-Seetharam, and Basuthkar J. Rao. "Chromosome territories reposition during DNA damage-repair response." Genome biology 14 (2013): 1-15.
23. Ramadasan-Nair, Renjini, Narayanappa Gayathri, Sudha Mishra, Balaraju Sunitha, Rajeswara Babu Mythri, Atchayaram Nalini, Yashwanth Subbannayya, Hindalahalli Chandregowda Harsha, Ullas Kolthur-Seetharam, and Muchukunte Mukunda Srinivas Bharath. "Mitochondrial alterations and oxidative stress in an acute transient mouse model of muscle degeneration: implications for muscular dystrophy and related muscle pathologies." Journal of Biological Chemistry 289, no. 1 (2014): 485-509.
24. El Ramy, Rosy, Najat Magroun, Nadia Messadecq, Laurent R. Gauthier, François D. Boussin, Ullas Kolthur-Seetharam, Valérie Schreiber, Michael W. McBurney, Paolo Sassone-Corsi, and Françoise Dantzer. "Functional interplay between Parp-1 and SirT1 in genome integrity and chromatin-based processes." Cellular and molecular life sciences 66 (2009): 3219-3234.
25. Monaco, Lucia, Ullas Kolthur-Seetharam, Romain Loury, Josiane Ménissier-de Murcia, Gilbert de Murcia, and Paolo Sassone-Corsi. "Inhibition of Aurora-B kinase activity by poly (ADP-ribosyl) ation in response to DNA damage." Proceedings of the National Academy of Sciences 102, no. 40 (2005): 14244-14248.
26. Meetei, Amom Ruhikanta, Kolathur S. Ullas, V. Vasupradha, and Manchanahalli R. Satyanarayana Rao. "Involvement of protein kinase A in the phosphorylation of spermatidal protein TP2 and its effect on DNA condensation." Biochemistry 41, no. 1 (2002): 185-195.
27. Meetei, Amom Ruhikanta, Kolathur S. Ullas, and Manchanahalli R. Satyanarayana Rao. "Identification of two novel zinc finger modules and nuclear localization signal in rat spermatidal protein TP2 by site-directed mutagenesis." Journal of Biological Chemistry 275, no. 49 (2000): 38500-38507.